Platelet-Rich Plasma (PRP) for Peripheral Neuropathy

  • Home
  • Platelet-Rich Plasma (PRP) for Peripheral Neuropathy

Platelet-Rich Plasma (PRP) for Peripheral Neuropathy

Platelet-Rich Plasma (PRP) therapy treats peripheral neuropathy by repairing damaged nerve tissue rather than just masking the symptoms. Standard ⁠neuropathy medications like pregabalin or gabapentin only temporarily block pain signals, whereas PRP introduces a highly concentrated wash of autologous growth factors that actively foster biological repair and nerve regeneration.

When a patient’s own concentrated plasma is injected around an inflamed or damaged nerve (a technique known as perineural injection), it initiates a specific multi-step healing process.

Core Biological Mechanisms

  • Stimulating Schwann Cells: PRP accelerates the activity, migration, and proliferation of Schwann cells. These specialized cells are directly responsible for producing and maintaining the myelin sheath—the protective insulating layer necessary for proper nerve signal transmission.
  • Promoting Axonal Regrowth: Bioactive molecules within PRP, such as Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), provide structural guidance and a supportive microenvironment. This triggers axonal sprouting and thickens the inner nerve fibers.
  • Restoring Blood Supply (Angiogenesis): Neuropathy often starves nerves of essential oxygen and metabolic nutrients. Growth factors like Vascular Endothelial Growth Factor (VEGF) in PRP trigger micro-vascular repair, creating new blood vessels to “re-feed” the damaged nerve pathways.
  • Calming Neuroinflammation: Platelets naturally store and release anti-inflammatory cytokines, such as Interleukin-10 (IL-10). These molecules shift the local environment away from chronic inflammation, measurably decreasing swelling and relieving localized pressure on the nerve.
Learn More

Clinical Application and Delivery

  • Ultrasound-Guided Injections: Specialists utilize real-time musculoskeletal ultrasound to map the inflamed nerve pathways. This visualization ensures the growth factors are deposited precisely into the surrounding tissue with minimal risk.
  • Nerve Hydrodissection: In cases where nerves are physically compressed or trapped by scar tissue, the mechanical fluid pressure of the injection is used to separate the nerve from the surrounding tissue. This restores blood flow and removes physical friction.
  • Notable Benefits Over Traditional Care: Clinical trials analyzing conditions like painful diabetic peripheral neuropathy indicate that ultrasound-guided PRP provides distinct advantages over conventional medical management:
Book Appointment

What to Expect

Your diagnostic visit is designed to be thorough yet comfortable. You’ll receive a detailed explanation of your results and how they guide your personalized care plan. We believe informed patients achieve better results, so we take the time to answer your questions and involve you in every step of the process.

Ready to get clear answers about your neuropathy and start a path toward real relief?

Call us today at (618) 622-2222 to schedule your comprehensive neuropathy diagnostic evaluation.

Learn More